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Phenotypes Associated with This Genotype
Genotype
MGI:7316565
Allelic
Composition		 A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Ppiftm1Jmol/Ppiftm1Jmol
Slc8b1tm1c(EUCOMM)Wtsi/Slc8b1tm1c(EUCOMM)Wtsi
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Ppiftm1Jmol mutation (1 available); any Ppif mutation (18 available)
Slc8b1tm1c(EUCOMM)Wtsi mutation (1 available); any Slc8b1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac hypertrophy ( J:325413 )
• near complete rescue in tamoxifen-treated mice
decreased heart ventricle muscle contractility ( J:325413 )
• near complete rescue in tamoxifen-treated mice

growth/size/body
cardiac hypertrophy ( J:325413 )
• near complete rescue in tamoxifen-treated mice

muscle
decreased heart ventricle muscle contractility ( J:325413 )
• near complete rescue in tamoxifen-treated mice
abnormal sarcomere morphology ( J:325413 )
• disorganization is nearly completely rescued in tamoxifen-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory