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Phenotypes Associated with This Genotype
Genotype
MGI:7316564
Allelic
Composition		 Slc8b1tm1c(EUCOMM)Wtsi/Slc8b1tm1c(EUCOMM)Wtsi
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Slc8b1tm1c(EUCOMM)Wtsi mutation (1 available); any Slc8b1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:325413 )
• most mice died within two weeks of tamoxifen treatment

cardiovascular system
increased myocardial fiber size ( J:325413 )
• increased cross-sectional area post tamoxifen-treatment
increased heart weight ( J:325413 )
• post tamoxifen-treatment
cardiac hypertrophy ( J:325413 )
• post tamoxifen-treatment
dilated heart left ventricle ( J:325413 )
• 3 days post tamoxifen-treatment
cardiac fibrosis ( J:325413 )
• post tamoxifen-treatment
decreased heart left ventricle muscle contractility ( J:325413 )
• decreased left ventricular function 3 days post tamoxifen-treatment as measured by fractional shortening and left ventricular end-diastolic dimension
decreased heart rate ( J:325413 )
• post tamoxifen-treatment
irregular heartbeat ( J:325413 )
• post tamoxifen-treatment only immediately before sinus arrest
prolonged PR interval ( J:325413 )
• post tamoxifen-treatment
prolonged QRS complex duration ( J:325413 )
• post tamoxifen-treatment
congestive heart failure ( J:325413 )
• post tamoxifen-treatment

growth/size/body
increased heart weight ( J:325413 )
• post tamoxifen-treatment
cardiac hypertrophy ( J:325413 )
• post tamoxifen-treatment

muscle
increased myocardial fiber size ( J:325413 )
• increased cross-sectional area post tamoxifen-treatment
decreased heart left ventricle muscle contractility ( J:325413 )
• decreased left ventricular function 3 days post tamoxifen-treatment as measured by fractional shortening and left ventricular end-diastolic dimension
abnormal sarcomere morphology ( J:325413 )
• disorganized post tamoxifen-treatment

cellular
dilated mitochondrion ( J:325413 )
• with disrupted calcium regulation in cardiomyocytes post tamoxifen-treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory