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Phenotypes Associated with This Genotype
Genotype
MGI:7314910
Allelic
Composition		 Ptgs2ostm1Scrp/Ptgs2ostm1Scrp
Genetic
Background		 Not Specified
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No mouse lines available in IMSR.
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased neutrophil cell number ( J:325487 )
• in the bronchoalveolar fluid of LPS-treated mice
abnormal chemokine level ( J:325487 )
• LPS-treated mice exhibit reduced serum and BAL levels of Ccl4, increased serum levels of Ccl5 and Ccl22 compared with wild-type mice
decreased CCL3 level ( J:325487 )
• in the bronchoalveolar fluid of LPS-treated mice
decreased circulating CCL3 level ( J:325487 )
• of LPS-treated mice
increased interferon-beta secretion ( J:325487 )
• in the bronchoalveolar fluid of LPS-treated mice

homeostasis/metabolism
abnormal chemokine level ( J:325487 )
• LPS-treated mice exhibit reduced serum and BAL levels of Ccl4, increased serum levels of Ccl5 and Ccl22 compared with wild-type mice
decreased CCL3 level ( J:325487 )
• in the bronchoalveolar fluid of LPS-treated mice
decreased circulating CCL3 level ( J:325487 )
• of LPS-treated mice

hematopoietic system
decreased neutrophil cell number ( J:325487 )
• in the bronchoalveolar fluid of LPS-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory