Phenotypes Associated with This Genotype

Genotype
MGI:7311736

• Allelic Composition: A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa; Tg(Rorc-cre)1Litt/0
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

immune system

abnormal interleukin secretion ( J:259392 )

• reduced IL22 secretion from intestinal lamina propria lymphocytes of C. rodentium exposed mice

increased susceptibility to bacterial infection ( J:259392 )

• C. rodentium-infected mice exhibit increased colon shortening, persistent intestinal damage, increased mortality, reduced IL22-secreting cells in the intestine, and IL22 secretion from intestinal lamina propria compared with control mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• reduced absolute numbers of ILC3 cells due to reduced proliferation

• however, ILC1 and ILC2s numbers are normal