Phenotypes Associated with This Genotype

Genotype
MGI:7311662

• Allelic Composition: Tg(COL2A1*R519C)#Afe/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal cartilage morphology ( J:307985 )

• decrease in the density of collagen fibrils in the interterritorial matrix

abnormal chondrocyte morphology ( J:307985 )

• articular chondrocytes display dilated Golgi cysternae

cellular

abnormal Golgi cisterna morphology ( J:307985 )

• articular chondrocytes display dilated Golgi cysternae

growth/size/body

growth/size/body region phenotype ( J:307985 )

N • unlike mice homozygous for the transgene, hemizygous mice are similar in size to wild-type controls and grossly normal at up to 6 months of age