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Phenotypes Associated with This Genotype
Genotype
MGI:7311617
Allelic
Composition		 Chd7tm2c(EUCOMM)Wtsi/Chd7tm2c(EUCOMM)Wtsi
Tg(Gdf9-icre)5092Coo/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * C57BL/6N
Cell Lines EPD0019_1_D07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd7tm2c(EUCOMM)Wtsi mutation (0 available); any Chd7 mutation (133 available)
Tg(Gdf9-icre)5092Coo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased granulosa cell apoptosis ( J:324165 )
• a TUNEL assay showed that the rate of granulosa cell apoptosis in adult ovaries is significantly higher than in heterozygous control ovaries, esp. in the preantral and early antral follicles
• IHC showed that the expression of cleaved caspase-3 positive cells is significantly higher than in control females
• however, granulosa cell proliferation is normal, as determined by Ki-67 staining
increased atretic ovarian follicle number ( J:324165 )
• the percentage of atretic follicles is significantly greater than in control females
impaired ovarian folliculogenesis ( J:324165 )
• H&E staining showed a significantly decreased number of ovarian follicles at all stages of folliculogenesis
small ovary ( J:324165 )
• at 8 weeks of age, ovaries are significantly smaller than in wild-type females
• however, body size is normal
decreased ovary weight ( J:324165 )
• at 8 weeks of age, ovary weights are significantly lower than in wild-type females
• however, body weight is normal
reduced female fertility ( J:324165 )
• when mated with wild-type males for 6 months, females produce a significantly lower number of litters than wild-type or heterozygous controls

endocrine/exocrine glands
increased granulosa cell apoptosis ( J:324165 )
• a TUNEL assay showed that the rate of granulosa cell apoptosis in adult ovaries is significantly higher than in heterozygous control ovaries, esp. in the preantral and early antral follicles
• IHC showed that the expression of cleaved caspase-3 positive cells is significantly higher than in control females
• however, granulosa cell proliferation is normal, as determined by Ki-67 staining
increased atretic ovarian follicle number ( J:324165 )
• the percentage of atretic follicles is significantly greater than in control females
impaired ovarian folliculogenesis ( J:324165 )
• H&E staining showed a significantly decreased number of ovarian follicles at all stages of folliculogenesis
small ovary ( J:324165 )
• at 8 weeks of age, ovaries are significantly smaller than in wild-type females
• however, body size is normal
decreased ovary weight ( J:324165 )
• at 8 weeks of age, ovary weights are significantly lower than in wild-type females
• however, body weight is normal

cellular
increased granulosa cell apoptosis ( J:324165 )
• a TUNEL assay showed that the rate of granulosa cell apoptosis in adult ovaries is significantly higher than in heterozygous control ovaries, esp. in the preantral and early antral follicles
• IHC showed that the expression of cleaved caspase-3 positive cells is significantly higher than in control females
• however, granulosa cell proliferation is normal, as determined by Ki-67 staining

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory