Phenotypes Associated with This Genotype

Genotype
MGI:7310455

• Allelic Composition: Nucb2^tm1.2Vdix/Nucb2^tm1.2Vdix
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:270674 )

N • mice fed a high-fat diet exhibit no difference in circulating leptin and adiponectin levels compared with wild-type mice

increased circulating free fatty acids level ( J:270674 )

• under clamped condition, mice fed a high-fat diet exhibit increased insulin-stimulated plasma free fatty acid compared with wild-type mice

abnormal glucose homeostasis ( J:270674 )

• mice fed a high-fat diet exhibit improved insulin sensitivity compared with wild-type mice

• however, mice fed a high-fat diet exhibit normal insulin levels

increased hepatic glucose production ( J:270674 )

• in mice fed a high-fat diet under clamped condition

immune system

increased interleukin-1 beta secretion ( J:270674 )

• from bone marrow-derived macrophages treated with LPS and IFNgamma

increased tumor necrosis factor secretion ( J:270674 )

• from bone marrow-derived macrophages treated with LPS and IFNgamma

growth/size/body

growth/size/body region phenotype ( J:270674 )

N • mice fed a high-fat diet exhibit normal diet-induced obesity

adipose tissue

adipose tissue phenotype ( J:270674 )

N • mice fed a high-fat diet exhibit no difference in adipocyte size or fat mass compared with wild-type mice