Phenotypes Associated with This Genotype

Genotype
MGI:7310444

• Allelic Composition: Smyd3^em1Yzzh/Smyd3^em1Yzzh
• Genetic Background: C57BL/6-Smyd3^em1Yzzh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta wall morphology ( J:296379 )

• Ang II-treated mice exhibit alleviated senescence-related thinning of the aorta compared with wild-type mice

abnormal systemic arterial blood pressure ( J:296379 )

• Ang II-treated mice exhibit decreased systolic blood pressure compared with wild-type mice

abnormal vasodilation ( J:296379 )

• Ang II-treated mice exhibit improved acetylcholine-induced endothelial-dependent relaxation compared with wild-type mice

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:296379 )

• Ang II-treated mice exhibit alleviated senescence-related phenotypes in the arteries, decreased systolic blood pressure, and improved acetylcholine-induced endothelial-dependent relaxation compared with wild-type mice

muscle

abnormal vasodilation ( J:296379 )

• Ang II-treated mice exhibit improved acetylcholine-induced endothelial-dependent relaxation compared with wild-type mice