Phenotypes Associated with This Genotype

Genotype
MGI:7310288

• Allelic Composition: Sinhcaf^tm1.2Hmd/Sinhcaf^tm1.2Hmd
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:313620 )

• mutants are detected at the expected frequency at E9.5 and E10.5, but numbers decline thereafter and are greatly decreased at E18.5 and mice are born at a frequency much lower than expected

cardiovascular system

abnormal cardiac outflow tract development ( J:313620 )

• embryos exhibit shortening of the outflow tract already at E9.5

abnormal heart development ( J:313620 )

• cell proliferation is reduced in the septum transversum, secondary heart field, and proepicardium at E9-E9.5 but is unaffected in the heart ventricle

double outlet right ventricle ( J:313620 )

• many mutants that survive to E18.5 exhibit double-outlet right ventricle

transposition of great arteries ( J:313620 )

• many mutants that survive to E18.5 exhibit transposition of the great arteries

ventricular septal defect ( J:313620 )

• many mutants that survive to E18.5 exhibit ventricular septum defects

small heart ( J:313620 )

• smaller at E13.5

heart right ventricle hypoplasia ( J:313620 )

digestive/alimentary system

abnormal digestive system development ( J:313620 )

• many mutants that survive to E18.5 exhibit abnormal rotation of the gut

• gut is smaller at E13.5

embryo

embryonic growth retardation ( J:313620 )

• embryos show growth retardation at E9.5

abnormal neural tube morphology ( J:313620 )

• embryos show neural tube defects at E9.5

• cell proliferation is slightly increased in the neural tube at E9-E9.5

abnormal septum transversum morphology ( J:313620 )

• cell proliferation is reduced in the septum transversum at E9-E9.5

growth/size/body

embryonic growth retardation ( J:313620 )

• embryos show growth retardation at E9.5

hematopoietic system

spleen hypoplasia ( J:313620 )

• many mutants that survive to E18.5 exhibit spleen hypoplasia

immune system

spleen hypoplasia ( J:313620 )

• many mutants that survive to E18.5 exhibit spleen hypoplasia

liver/biliary system

small liver ( J:313620 )

• smaller at E13.5

nervous system

abnormal neural tube morphology ( J:313620 )

• embryos show neural tube defects at E9.5

• cell proliferation is slightly increased in the neural tube at E9-E9.5

respiratory system

impaired lung lobe morphogenesis ( J:313620 )

• many mutants that survive to E18.5 exhibit incomplete lobulation of the lungs