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Phenotypes Associated with This Genotype
Genotype
MGI:7310259
Allelic
Composition		 Izumo3tm1Osb/Izumo3tm1Osb
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Izumo3tm1Osb mutation (1 available); any Izumo3 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal acrosome morphology ( J:324147 )
• abnormal acrosomal granule positioning

reproductive system
abnormal acrosome morphology ( J:324147 )
• abnormal acrosomal granule positioning
reduced male fertility ( J:324147 )
• male mice produced smaller litter size

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory