Analysis Tools
craniofacial
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• at E14.5, mice show a higher proliferation index per unit area (PIPUA) within palatal shelf mesenchyme than double heterozygous controls, but to a lesser extent than in Boctm1Aok homozygotes (which have the lowest cell packing index (CPI) value and highest PIPUA value amongst genotypes)
• however, the CPI value is not statistically different from that in double heterozygous controls
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• at E12.5, expression levels of Shh and its target genes Ptch1 and Gli1 are reduced, indicating reduced Shh activity in the palatal shelves during palate development
• at E14.5, TUNEL assays showed lower levels of apoptosis within anterior, medial and posterior sections of the palatal shelves than in double heterozygous controls
• despite increased mesenchymal proliferation and reduced epithelial cell death, palatal shelf size is similar to that in double heterozygous controls
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cleft palate
(
J:310333
)
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• at E14.5, mice exhibit a fully penetrant cleft palate
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• at E14.5, mice show failure of palatal shelf (PS) elevation above the tongue
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bifid tongue
(
J:310333
)
|
• at E14.5, a midline cleft is noted within the posterior third of the tongue in the pharyngeal region
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• at E14.5, the vomeronasal organ is abnormally positioned
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digestive/alimentary system
|
• at E14.5, mice show a higher proliferation index per unit area (PIPUA) within palatal shelf mesenchyme than double heterozygous controls, but to a lesser extent than in Boctm1Aok homozygotes (which have the lowest cell packing index (CPI) value and highest PIPUA value amongst genotypes)
• however, the CPI value is not statistically different from that in double heterozygous controls
|
|
• at E12.5, expression levels of Shh and its target genes Ptch1 and Gli1 are reduced, indicating reduced Shh activity in the palatal shelves during palate development
• at E14.5, TUNEL assays showed lower levels of apoptosis within anterior, medial and posterior sections of the palatal shelves than in double heterozygous controls
• despite increased mesenchymal proliferation and reduced epithelial cell death, palatal shelf size is similar to that in double heterozygous controls
|
cleft palate
(
J:310333
)
|
• at E14.5, mice exhibit a fully penetrant cleft palate
|
|
• at E14.5, mice show failure of palatal shelf (PS) elevation above the tongue
|
bifid tongue
(
J:310333
)
|
• at E14.5, a midline cleft is noted within the posterior third of the tongue in the pharyngeal region
|
growth/size/body
|
• at E14.5, mice show a higher proliferation index per unit area (PIPUA) within palatal shelf mesenchyme than double heterozygous controls, but to a lesser extent than in Boctm1Aok homozygotes (which have the lowest cell packing index (CPI) value and highest PIPUA value amongst genotypes)
• however, the CPI value is not statistically different from that in double heterozygous controls
|
|
• at E12.5, expression levels of Shh and its target genes Ptch1 and Gli1 are reduced, indicating reduced Shh activity in the palatal shelves during palate development
• at E14.5, TUNEL assays showed lower levels of apoptosis within anterior, medial and posterior sections of the palatal shelves than in double heterozygous controls
• despite increased mesenchymal proliferation and reduced epithelial cell death, palatal shelf size is similar to that in double heterozygous controls
|
cleft palate
(
J:310333
)
|
• at E14.5, mice exhibit a fully penetrant cleft palate
|
|
• at E14.5, mice show failure of palatal shelf (PS) elevation above the tongue
|
bifid tongue
(
J:310333
)
|
• at E14.5, a midline cleft is noted within the posterior third of the tongue in the pharyngeal region
|
|
• at E14.5, the vomeronasal organ is abnormally positioned
|
nervous system
|
• at E14.5, the vomeronasal organ is abnormally positioned
|
respiratory system
|
• at E14.5, the vomeronasal organ is abnormally positioned
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