Analysis Tools
reproductive system
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• male mice are fertile and show no apparent defects in spermatogenesis, epididymal sperm number, sperm motility or meiotic progression relative to control males
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• chromosome spreads prepared from 28dpp testes show a significantly higher % of spermatocytes that retain gammaH2AX on the autosomes in pachytene and diplotene spermatocytes (where normally gammaH2AX is found only on the XY body)
• however, no significant increase in apoptosis is observed, as determined by a TUNEL assay
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cellular
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• chromosome spreads prepared from 28dpp testes show a significantly higher % of spermatocytes that retain gammaH2AX on the autosomes in pachytene and diplotene spermatocytes (where normally gammaH2AX is found only on the XY body)
• however, no significant increase in apoptosis is observed, as determined by a TUNEL assay
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