Phenotypes Associated with This Genotype

Genotype
MGI:7281135

• Allelic Composition: Mbtps1^tm1Jdh/Mbtps1⁺; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:258274 )

• heterozygous mice are smaller than wild-type or recombinase expressing controls but larger than homozygous mice

skeleton

abnormal appendicular skeleton morphology ( J:258274 )

• smaller appendicular elements, intermediate to homozygous mice

abnormal axial skeleton morphology ( J:258274 )

• smaller axial elements, intermediate to homozygous mice

abnormal compact bone thickness ( J:258274 )

• mid-diaphyseal cortical bone is smaller in width but not reduced in thickness

abnormal bone ossification ( J:258274 )

• osteogenic capacity of bone marrow stem cells is absent in vitro