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Phenotypes Associated with This Genotype
Genotype
MGI:7278774
Allelic
Composition		 Acvr1tm1Glh/Acvr1tm1Vk
Gt(ROSA)26Sortm1.2(CAG-EGFP)Glh/Gt(ROSA)26Sor+
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Glh mutation (0 available); any Acvr1 mutation (43 available)
Acvr1tm1Vk mutation (0 available); any Acvr1 mutation (43 available)
Gt(ROSA)26Sortm1.2(CAG-EGFP)Glh mutation (0 available); any Gt(ROSA)26Sor mutation (1095 available)
Tg(Tek-cre)1Ywa mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal response to injury ( J:257905 )
• pinch injury of adult gastrocnemius muscle results in a 50-fold increase in heterotopic ossification volume compared to mice that have one wild-type allele of Acvr1

skeleton
increased bone ossification ( J:257905 )
• pinch injury of adult gastrocnemius muscle results in a 50-fold increase in heterotopic ossification volume compared to mice that have one wild-type allele of Acvr1

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory