Phenotypes Associated with This Genotype

Genotype
MGI:7276255

• Allelic Composition: Nppc^lbab/Nppc^lbab; Tg(Col2a1-Nppc)1Yog/0
• Genetic Background: involves: C57BL/6J * PL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:321139 )

• body weight is decreased until 3 weeks of age but then promptly increases to wild-type levels

decreased body length ( J:321139 )

• the nasoanal length is smaller at the first week after birth, however subsequently mice begin to grow and catch up with wild-type mice after 4 weeks of age

skeleton

skeleton phenotype ( J:321139 )

N • the impaired growth of bones formed through endochondral ossification seen in Nppc^lbab mice is partially recovered at 2 weeks of age and almost completely recovered by 10 weeks of age and the reduction in bone volume and trabecular thickness of humerus seen in single Nppc^lbab homozygotes is rescued

decreased width of hypertrophic chondrocyte zone ( J:321139 )

• the thinner hypertrophic chondrocyte layer is considerably recovered but not completely

• however, proliferative chondrocyte layer is normal and tibial growth plate thickness is normal at 10 weeks of age