Analysis Tools
reproductive system
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• oocytes show a significantly greater number of bivalents lacking MLH1 foci than wild-type oocytes at pachynema (3.9% versus 2.1%) but no significant differences at diplonema, suggesting a delay in crossover formation rather than an inability to form crossovers
• however, meiotic prophase progression is grossly unaffected
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• prepubertal and adult ovaries show a 5-fold and a 9-fold increase, respectively, in granulosa cell apoptosis in small secondary follicles
• however, the rate of granulosa cell apoptosis is not significantly altered in primary follicles at either age
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• adult ovaries show a significantly reduced proportion of EdU+ granulosa cells in primary follicles
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• both prepubertal and adult ovaries show a significantly increased proportion of EdU+ granulosa cells in small secondary follicles
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• growing follicles are smaller than those found in control ovaries
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• adult ovaries show a significant reduction in primary follicles
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• adult ovaries show a 3-fold increase in the number of primordial follicles
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• adult ovaries show a significant reduction in secondary follicles
• however, the number of antral follicles is normal
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• adult females show altered folliculogenesis progression resulting in a reduction of growing follicles
• adult ovaries show significantly reduced granulosa cell proliferation in primary follicles but increased granulosa cell proliferation in small secondary follicles
• both prepubertal and adult ovaries show a significantly higher proportion of TUNEL+ apoptotic granulosa and theca cells in small secondary follicles than control ovaries
• however, no differences in the proportion of EdU+ theca cells are seen in P21 or adult mice
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cellular
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• oocytes show a significantly greater number of bivalents lacking MLH1 foci than wild-type oocytes at pachynema (3.9% versus 2.1%) but no significant differences at diplonema, suggesting a delay in crossover formation rather than an inability to form crossovers
• however, meiotic prophase progression is grossly unaffected
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• prepubertal and adult ovaries show a 5-fold and a 9-fold increase, respectively, in granulosa cell apoptosis in small secondary follicles
• however, the rate of granulosa cell apoptosis is not significantly altered in primary follicles at either age
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• adult ovaries show a significantly reduced proportion of EdU+ granulosa cells in primary follicles
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• both prepubertal and adult ovaries show a significantly increased proportion of EdU+ granulosa cells in small secondary follicles
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endocrine/exocrine glands
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• prepubertal and adult ovaries show a 5-fold and a 9-fold increase, respectively, in granulosa cell apoptosis in small secondary follicles
• however, the rate of granulosa cell apoptosis is not significantly altered in primary follicles at either age
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• adult ovaries show a significantly reduced proportion of EdU+ granulosa cells in primary follicles
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• both prepubertal and adult ovaries show a significantly increased proportion of EdU+ granulosa cells in small secondary follicles
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• growing follicles are smaller than those found in control ovaries
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• adult ovaries show a significant reduction in primary follicles
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• adult ovaries show a 3-fold increase in the number of primordial follicles
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• adult ovaries show a significant reduction in secondary follicles
• however, the number of antral follicles is normal
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• adult females show altered folliculogenesis progression resulting in a reduction of growing follicles
• adult ovaries show significantly reduced granulosa cell proliferation in primary follicles but increased granulosa cell proliferation in small secondary follicles
• both prepubertal and adult ovaries show a significantly higher proportion of TUNEL+ apoptotic granulosa and theca cells in small secondary follicles than control ovaries
• however, no differences in the proportion of EdU+ theca cells are seen in P21 or adult mice
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