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Phenotypes Associated with This Genotype
Genotype
MGI:7261399
Allelic
Composition		 Tshz3tm2.1Lafa/Tshz3tm2.1Lafa
Tg(Camk2a-cre)2Gsc/0
Tg(Thy1-EGFP)#Jrs/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-cre)2Gsc mutation (2 available)
Tg(Thy1-EGFP)#Jrs mutation (0 available)
Tshz3tm2.1Lafa mutation (0 available); any Tshz3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased dendritic spine density ( J:294534 )
• mice show reduced spine density in layer 5 cortical projection neurons
• however, no major changes in overall cortical projection neurons morphology and projections are seen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory