Phenotypes for Lhx8 MGI:7259843 MGI Mouse

reproductive system phenotype ( J:140898 )

N	• adult male mice are fertile, produce normal litter sizes, and show normal testis size, morphology and histology relative to wild-type males

decreased oocyte number ( J:140898 )

• very few oocytes remain at P7; rapid loss of oocytes may partly be due to >7-fold downregulation of prosurvival factor Kit and its ligand Kitl in the newborn ovary

• however, number of oocytes is normal in the newborn ovary

absent oocytes ( J:140898 )

• adult ovaries contain no oocytes

oocyte degeneration ( J:140898 )

• at P7, ovaries contain very few oocytes and most follicles are degenerating

decreased primordial ovarian follicle number ( J:140898 )

• number of primordial follicles is significantly reduced in the newborn ovary

absent primordial ovarian follicles ( J:140898 )

• no primordial follicles are found at P7

absent ovarian follicles ( J:140898 )

• adult ovaries contain no follicles

impaired ovarian folliculogenesis ( J:140898 )

• transition from primordial to growing follicles does not occur

ovary atrophy ( J:140898 )

• ovaries are atrophic at 10 weeks of age

• however, newborn ovaries are grossly normal in morphology and histology

abnormal uterine horn morphology ( J:140898 )

• uterine horns are atrophic at 10 weeks of age

female infertility ( J:140898 )

• all females are infertile