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Phenotypes Associated with This Genotype
Genotype
MGI:6887989
Allelic
Composition		 Droshatm1Litt/Droshatm1Litt
Wt1tm2(cre/ERT2)Wtp/Wt1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Droshatm1Litt mutation (3 available); any Drosha mutation (98 available)
Wt1tm2(cre/ERT2)Wtp mutation (1 available); any Wt1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:321428 )
N
• normal kidney size with fully developed glomeruli
increased urine protein level ( J:321428 )
• protein deposits in kidney tubules by age P28

homeostasis/metabolism
increased urine protein level ( J:321428 )
• protein deposits in kidney tubules by age P28

neoplasm
neoplasm ( J:321428 )
N
• no kidney tumor development in mice up to 6 months old

mortality/aging
mortality/aging ( J:321428 )
N
• viable; live to at least 6 months

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory