Phenotypes Associated with This Genotype

Genotype
MGI:6856674

• Allelic Composition: Furin^tm1Jwmc/Furin^tm1Jwmc; Tg(Gdf9-icre)5092Coo/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased granulosa cell proliferation ( J:272231 )

♀ • PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age

increased secondary ovarian follicle number ( J:272231 )

♀ • number of early secondary follicles is significantly increased at 6 weeks of age

impaired ovarian folliculogenesis ( J:272231 )

♀ • ovarian follicle development is arrested at the early secondary follicle stage

♀ • however, number of primordial follicles is normal at 2 months of age, suggesting that survival and activation of primordial follicles is unaffected

female infertility ( J:272231 )

♀

cellular

decreased granulosa cell proliferation ( J:272231 )

♀ • PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age

endocrine/exocrine glands

decreased granulosa cell proliferation ( J:272231 )

♀ • PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age

increased secondary ovarian follicle number ( J:272231 )

♀ • number of early secondary follicles is significantly increased at 6 weeks of age

impaired ovarian folliculogenesis ( J:272231 )

♀ • ovarian follicle development is arrested at the early secondary follicle stage

♀ • however, number of primordial follicles is normal at 2 months of age, suggesting that survival and activation of primordial follicles is unaffected