Phenotypes Associated with This Genotype

Genotype
MGI:6836760

• Allelic Composition: Atm^tm2.1Mfgc/Atm^tm2.1Mfgc
• Genetic Background: C57BL/6-Atm^tm2.1Mfgc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:316365 )

• mice exhibit reduced survivability with 42% of mice still alive at 400 days of age

premature death ( J:316365 )

• about 1/3 of mice die from complications related to large thymic cancers in the thoracic cavity

neoplasm

increased thymoma incidence ( J:316365 )

immune system

abnormal T cell differentiation ( J:316365 )

• mice show decreased expression of CD4+CD8- and CD4-CD8+ single positive thymocytes, indicating impaired thymocyte maturation

decreased T cell number ( J:316365 )

• reduction in the total fraction of CD3+ T-cells in the peripheral blood

hematopoietic system

abnormal T cell differentiation ( J:316365 )

• mice show decreased expression of CD4+CD8- and CD4-CD8+ single positive thymocytes, indicating impaired thymocyte maturation

decreased T cell number ( J:316365 )

• reduction in the total fraction of CD3+ T-cells in the peripheral blood

behavior/neurological

behavior/neurological phenotype ( J:316365 )

N • mice do not exhibit ataxia at P460