Phenotypes Associated with This Genotype

Genotype
MGI:6829617

• Allelic Composition: Mirc13^tm1Biat/Mirc13⁺; Mirc4^tm1.1Biat/Mirc4^tm1.1Biat; Tg(Ins2-cre)23Herr/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:314874 )

N • streptozotocin-treated mice develop hyperglycemia as in wild-type mice

abnormal circulating glucose level ( J:314874 )

• streptozotocin-treated mice exhibit increased glucose serum levels that is not as severe as in wild-type mice

decreased physiological sensitivity to xenobiotic ( J:314874 )

• streptozotocin-treated mice exhibit reduced apoptosis and elevation of glucose serum levels compared with controls but not as much as in double null mice

endocrine/exocrine glands

abnormal pancreatic beta cell apoptosis ( J:314874 )

• streptozotocin-treated mice exhibit reduced apoptosis compared with controls but not as much as in double null mice

cellular

abnormal pancreatic beta cell apoptosis ( J:314874 )

• streptozotocin-treated mice exhibit reduced apoptosis compared with controls but not as much as in double null mice