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Phenotypes Associated with This Genotype
Genotype
MGI:6827384
Allelic
Composition
Kif9em2Osb/Kif9em2Osb
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * C57BL/6NSlc * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif9em2Osb mutation (2 available); any Kif9 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• velocity parameters including average path velocity (VAP), straight line velocity (VSL) and curvilinear velocity (VCL) are all significantly reduced, as observed in mice homozygous for the Kif9em1Osb allele
• however, the % of motile spermatozoa is comparable to than in heterozygous controls
• sperm motility is impaired, as observed in mice homozygous for the Kif9em1Osb allele
• when mated with wild-type females, males yield a significantly lower number of litters born per plug relative to wild-type males, as observed in mice homozygous for the Kif9em1Osb allele

cellular
• velocity parameters including average path velocity (VAP), straight line velocity (VSL) and curvilinear velocity (VCL) are all significantly reduced, as observed in mice homozygous for the Kif9em1Osb allele
• however, the % of motile spermatozoa is comparable to than in heterozygous controls
• sperm motility is impaired, as observed in mice homozygous for the Kif9em1Osb allele

nervous system
N
• mice do NOT exhibit overt hydrocephalus, consistent with mice homozygous for the Kif9em1Osb allele


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory