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Phenotypes Associated with This Genotype
Genotype
MGI:6822329
Allelic
Composition		 Ifih1tm1.1Cln/Ifih1tm1.1Cln
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifih1tm1.1Cln mutation (5 available); any Ifih1 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-beta secretion ( J:240099 )
• induction of IFN-beta mRNA expression in bone marrow derived macrophages (BMDMs) is abrogated following infection with encephalomyocarditis virus (EMCV), or after stimulation with HMW poly I:C or EMCV-RNA
• in contrast, IFN-beta mRNA expression in BMDMs is normal following infection with vesicular stomatitis virus (VSV, Indiana strain), or after stimulation with LMW poly I:C or VSV-RNA

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory