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Phenotypes Associated with This Genotype
Genotype
MGI:6822318
Allelic
Composition		 Rprd1btm1Tshu/Rprd1btm1Tshu
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Tg(Vil1-cre)20Syr/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (57 available)
Rprd1btm1Tshu mutation (0 available); any Rprd1b mutation (16 available)
Tg(Vil1-cre)20Syr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal digestive system development ( J:300857 )
• decreased Lgr5-GFP+ cells pre and post tamoxifen treatment
• tamoxifen-treated cultured intestinal crypt organoids exhibit fewer outgrowths and fail to reform after disaggregation unlike control cultures

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory