Phenotypes Associated with This Genotype

Genotype
MGI:6766537

• Allelic Composition: Notch2^tm1.1Hhtg/Notch2^tm1.1Hhtg
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:311038 )

• more than 60% of mice do not survive the first 5 weeks

skeleton

abnormal vertebral body morphology ( J:311038 )

• 4-week-old mice show a decrease in vertebral body height

decreased bone mineral density of femur ( J:311038 )

• surviving 24-week-old mice show trabecular and cortical osteopenia in the femurs

• however, no significant changes are seen in calcium, phosphorus, glucose, and beta-c-terminal telopeptide serum levels