Phenotypes for Ifi35 MGI:6764604 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ifi35^em1Hhl/Ifi35^em1Hhl
Genetic Background	C57BL/6-Ifi35^em1Hhl

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifi35^em1Hhl mutation (0 available); any Ifi35 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:298909 )

• after LPS intraperitoneal injection

immune system

decreased circulating interleukin-6 level ( J:298909 )

• after LPS intraperitoneal injection

decreased circulating tumor necrosis factor level ( J:298909 )

• after LPS intraperitoneal injection

decreased susceptibility to endotoxin shock ( J:298909 )

• improved survival after LPS intraperitoneal injection and reduced serum TNF and IL6 levels compared with wild-type mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:298909 )

• after LPS intraperitoneal injection

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:298909 )

• after LPS intraperitoneal injection

decreased circulating tumor necrosis factor level ( J:298909 )

• after LPS intraperitoneal injection

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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