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Phenotypes Associated with This Genotype
Genotype
MGI:6763955
Allelic
Composition
Tg(Myh6-Grem2)1Akh/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• no significant alterations in heart size, cardiac tissue morphology or cardiac function at 12 weeks of age under baseline conditions
• improved cardiac function with higher fractional shortening and ejection fraction values relative to wild-type controls at day 21 post MI
• enhanced functional recovery due to preservation of both diastolic and systolic left ventricular internal diameters with lower overall values than control mice at day 21 post MI
• attenuated induction levels of genes encoding endothelial cell-specific adhesion membrane proteins, Sele and Vcam1, at day 2 post MI, with no significant changes in the induction of proinflammatory cytokines
• decreased numbers of CD45+, Ly6C+ (intermediate and high expression levels) and F4/80+ cells in cardiac tissue at day 5 post MI
• reduced induction levels of Tgfbeta1 and Il10 in the heart post MI

immune system
• reduced induction levels of Il10 in the heart at day 2 post MI
• reduced magnitude of the inflammatory response after myocardial infarction (MI) by permanent ligation of the left anterior descending coronary artery

homeostasis/metabolism
• attenuated induction levels of genes encoding endothelial cell-specific adhesion membrane proteins, Sele and Vcam1, at day 2 post MI, with no significant changes in the induction of proinflammatory cytokines
• decreased numbers of CD45+, Ly6C+ (intermediate and high expression levels) and F4/80+ cells in cardiac tissue at day 5 post MI
• reduced induction levels of Tgfbeta1 and Il10 in the heart post MI
• reduced induction levels of Tgfbeta1 in the heart at day 7 post MI

muscle
• improved cardiac function with higher fractional shortening and ejection fraction values relative to wild-type controls at day 21 post MI
• enhanced functional recovery due to preservation of both diastolic and systolic left ventricular internal diameters with lower overall values than control mice at day 21 post MI


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory