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Phenotypes Associated with This Genotype
Genotype
MGI:6753376
Allelic
Composition		 Tg(Map1a)56Pjn/0
Tubtub/Tubtub
Genetic
Background		 B6(AU)-Tubtub Tg(Map1a)56Pjn/Pjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Map1a)56Pjn mutation (1 available)
Tubtub mutation (3 available); any Tub mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye morphology ( J:196742 )
• Background Sensitivity: The presence of the 129P2/OlaHsd allele of Map1a from the transgene rescues some of the photoreceptor degeneration that occurs in tubby homozygotes on a predominantly C57BL/6J background, with an average of 126 photoreceptor nuclei remaining in the outer nuclear layer in the presence of the transgene but only 76 in the tubby homozygotes lacking this transgene

hearing/vestibular/ear
abnormal hearing physiology ( J:75815 )
• Background Sensitivity: The 129P2/OlaHsd-derived sequence of this transgene rescues much of the hearing loss phenotype of tubby homozygotes on the C57BL/6J background

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory