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Phenotypes Associated with This Genotype
Genotype
MGI:6728089
Allelic
Composition		 Txndc5em1Ntuh/Txndc5em1Ntuh
Genetic
Background		 C57BL/6J-Txndc5em1Ntuh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Txndc5em1Ntuh mutation (0 available); any Txndc5 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac fibrosis ( J:307898 )
• minimal in response to isoproterenol treatment
abnormal myocardial fiber physiology ( J:307898 )
• reduced proliferative activity in response to TGFbeta1 stimulation
decreased response of heart to induced stress ( J:307898 )
• isoproterenol-treated mice exhibit no increased heart weight and reduced cardiac fibrosis and myocardial dysfunction compared with wild-type mice

homeostasis/metabolism
decreased response of heart to induced stress ( J:307898 )
• isoproterenol-treated mice exhibit no increased heart weight and reduced cardiac fibrosis and myocardial dysfunction compared with wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory