Phenotypes for Gucy1b2 Hmox2 MGI:6725099 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gucy1b2^tm3Mom/Gucy1b2^tm3Mom Hmox2^tm1Poss/Hmox2^tm1Poss
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy1b2^tm3Mom mutation (1 available); any Gucy1b2 mutation (33 available)
Hmox2^tm1Poss mutation (1 available); any Hmox2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal physiological response to hypoxia ( J:307157 )

• Type B olfactory sensory neurons of the main olfactory epithelium respond normally to NaHS but not reduced oxygen with HMOX2 absent from type B olfactory sensory neurons, homozygotes fail to respond to hypoxia by the usual avoidance behavior and increased stress-induced self-grooming that occurs in controls, but respond with normal avoidance and increased self-grooming in response to NaHS

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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