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Phenotypes Associated with This Genotype
Genotype
MGI:6724575
Allelic
Composition		 Jmytm1Smoc/Jmytm1Smoc
Tg(Amh-cre)8815Reb/0
Genetic
Background		 involves: 129S * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jmytm1Smoc mutation (0 available); any Jmy mutation (33 available)
Tg(Amh-cre)8815Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
enlarged sperm head ( J:307721 )
• enlarged deformed sperm head ratio
asthenozoospermia ( J:307721 )
• reduced motility
abnormal seminiferous tubule morphology ( J:307721 )
• loose arrangements between spermatogenic cells and Sertoli cells with abscission of round spermatids in the lumen of the seminiferous tubule
abnormal Sertoli cell barrier function ( J:307721 )
• loose arrangements between spermatogenic cells and Sertoli cells and disrupted endosomal recycling
decreased litter size ( J:307721 )
• reduced litter size from male mice
reduced male fertility ( J:307721 )
• reduced litter size from male mice

cellular
enlarged sperm head ( J:307721 )
• enlarged deformed sperm head ratio
asthenozoospermia ( J:307721 )
• reduced motility

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:307721 )
• loose arrangements between spermatogenic cells and Sertoli cells with abscission of round spermatids in the lumen of the seminiferous tubule
abnormal Sertoli cell barrier function ( J:307721 )
• loose arrangements between spermatogenic cells and Sertoli cells and disrupted endosomal recycling

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory