Phenotypes Associated with This Genotype

Genotype
MGI:6724442

• Allelic Composition: Prrc2a^tm1Fcw/Prrc2a^tm1Fcw; Olig2^{tm2(TVA,cre)Rth}/Olig2⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:301796 )

nervous system

nervous system phenotype ( J:301796 )

N • mice exhibit normal ventral neuron numbers in the spinal cord

decreased oligodendrocyte number ( J:301796 )

abnormal brain morphology ( J:301796 )

• however, neuron number is normal

decreased oligodendrocyte progenitor number ( J:301796 )

increased brain weight ( J:301796 )

enlarged lateral ventricles ( J:301796 )

abnormal corpus callosum morphology ( J:301796 )

• increased signal density on MRIs

• hypomyelination in the corpus callosum at 4 weeks of age and in adults

dysmyelination ( J:301796 )

growth/size/body

decreased body weight ( J:301796 )

behavior/neurological

impaired spatial learning ( J:301796 )

impaired coordination ( J:301796 )

decreased grip strength ( J:301796 )

cellular

decreased oligodendrocyte number ( J:301796 )

decreased oligodendrocyte progenitor number ( J:301796 )