Phenotypes Associated with This Genotype

Genotype
MGI:6719237

• Allelic Composition: Rab26^em1Guwa/Rab26^em1Guwa
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal susceptibility to injury induced morbidity/mortality ( J:306921 )

• mice exhibit higher mortality than wild-type controls in response to a sublethal dose of LPS

increased susceptibility to injury ( J:306921 )

• mice show aggravated LPS-induced acute lung injury, showing more congestion, alveolar collapse, thickening of the alveolar walls, a dramatic increase in bronchoalveolar lavage fluid protein content, lung edema, and pulmonary microvascular permeability in the lungs compared to wild-type controls

immune system

increased susceptibility to endotoxin shock ( J:306921 )

• mice show aggravated LPS-induced acute lung injury, showing more congestion, alveolar collapse, thickening of the alveolar walls, a dramatic increase in bronchoalveolar lavage fluid protein content, lung edema, and pulmonary microvascular permeability in the lungs compared to wild-type controls

• mice exhibit higher mortality than wild-type controls in response to a sublethal dose of LPS

• however, mice do not show changes in the lungs under physiological conditions

mortality/aging

abnormal susceptibility to injury induced morbidity/mortality ( J:306921 )

• mice exhibit higher mortality than wild-type controls in response to a sublethal dose of LPS