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Phenotypes Associated with This Genotype
Genotype
MGI:6719029
Allelic
Composition		 Bcap31tm1.1Bwang/Bcap31tm1.1Bwang
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcap31tm1.1Bwang mutation (0 available); any Bcap31 mutation (8 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased thymocyte apoptosis ( J:274469 )
• accelerated apoptosis in freshly isolated thymocytes after tunicamycin treatment
small thymus ( J:274469 )
• decreased thymus size in young adult (3-, 5- or 8-week-old) and older mice (6-month-old)
decreased thymus weight ( J:274469 )
• decreased thymus weight in young adult and older mice
decreased thymocyte number ( J:274469 )
• reduced total thymocyte number in young adult and older mice
• however, development of double-negative (DN) thymocytes and CD4+ and CD8+ single-positive (SP) thymocytes is normal
• no significant change in DN1-4 thymic subsets
decreased CD8-positive, naive alpha-beta T cell number ( J:274469 )
• decreased % of naive (CD44lowCD62Lhi) in CD4+ and CD8+ T cells in the spleen and lymph nodes of young adult (8-wk-old) and older mice (6-mo-old)
increased effector memory T-helper cell number ( J:274469 )
• increased % of effector/memory T cells (CD44hiCD62Llo) in CD4+ and CD8+ T cells in the spleen and lymph nodes of young adult (8-wk-old) and older mice (6-mo-old)
decreased single-positive T cell number ( J:274469 )
• decreased percentage of CD4+ and CD8+ single positive (SP) mature T lymphocytes in the spleen and lymph nodes of young adult (3-, 5- or 8-week-old) and older mice (6-month-old)
• decreased percentage of CD4+ and CD8+ T cells in peripheral blood
• however, expression of class I MHC molecules on CD4+ and CD8+ SP splenocytes is normal
abnormal T cell activation ( J:274469 )
• marked reduction in IL-2 and IFN-gamma production following stimulation of total splenocytes with anti-CD3 plus anti-CD28
decreased T cell proliferation ( J:274469 )
• reduced T cell proliferation following stimulation of total splenocytes with anti-CD3 plus anti-CD28
decreased interferon-gamma secretion ( J:274469 )
• marked reduction in IFN-gamma production following stimulation of total splenocytes with anti-CD3 plus anti-CD28; also detected at the mRNA level
decreased interleukin-2 secretion ( J:274469 )
• marked reduction in IL-2 production following stimulation of total splenocytes with anti-CD3 plus anti-CD28; also detected at the mRNA level

hematopoietic system
increased thymocyte apoptosis ( J:274469 )
• accelerated apoptosis in freshly isolated thymocytes after tunicamycin treatment
small thymus ( J:274469 )
• decreased thymus size in young adult (3-, 5- or 8-week-old) and older mice (6-month-old)
decreased thymus weight ( J:274469 )
• decreased thymus weight in young adult and older mice
decreased thymocyte number ( J:274469 )
• reduced total thymocyte number in young adult and older mice
• however, development of double-negative (DN) thymocytes and CD4+ and CD8+ single-positive (SP) thymocytes is normal
• no significant change in DN1-4 thymic subsets
decreased CD8-positive, naive alpha-beta T cell number ( J:274469 )
• decreased % of naive (CD44lowCD62Lhi) in CD4+ and CD8+ T cells in the spleen and lymph nodes of young adult (8-wk-old) and older mice (6-mo-old)
increased effector memory T-helper cell number ( J:274469 )
• increased % of effector/memory T cells (CD44hiCD62Llo) in CD4+ and CD8+ T cells in the spleen and lymph nodes of young adult (8-wk-old) and older mice (6-mo-old)
decreased single-positive T cell number ( J:274469 )
• decreased percentage of CD4+ and CD8+ single positive (SP) mature T lymphocytes in the spleen and lymph nodes of young adult (3-, 5- or 8-week-old) and older mice (6-month-old)
• decreased percentage of CD4+ and CD8+ T cells in peripheral blood
• however, expression of class I MHC molecules on CD4+ and CD8+ SP splenocytes is normal
abnormal T cell activation ( J:274469 )
• marked reduction in IL-2 and IFN-gamma production following stimulation of total splenocytes with anti-CD3 plus anti-CD28
decreased T cell proliferation ( J:274469 )
• reduced T cell proliferation following stimulation of total splenocytes with anti-CD3 plus anti-CD28

cellular
increased thymocyte apoptosis ( J:274469 )
• accelerated apoptosis in freshly isolated thymocytes after tunicamycin treatment
decreased T cell proliferation ( J:274469 )
• reduced T cell proliferation following stimulation of total splenocytes with anti-CD3 plus anti-CD28

endocrine/exocrine glands
increased thymocyte apoptosis ( J:274469 )
• accelerated apoptosis in freshly isolated thymocytes after tunicamycin treatment
small thymus ( J:274469 )
• decreased thymus size in young adult (3-, 5- or 8-week-old) and older mice (6-month-old)
decreased thymus weight ( J:274469 )
• decreased thymus weight in young adult and older mice
decreased thymocyte number ( J:274469 )
• reduced total thymocyte number in young adult and older mice
• however, development of double-negative (DN) thymocytes and CD4+ and CD8+ single-positive (SP) thymocytes is normal
• no significant change in DN1-4 thymic subsets

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory