Phenotypes Associated with This Genotype

Genotype
MGI:6718866

• Allelic Composition: Upf2^tm1Btp/Upf2^tm1Btp; Tg(Atoh1-cre)1Bfri/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuronal precursor proliferation ( J:306384 )

• reduced fraction of granule cell precursors exiting the cell cycle in the anterior lobes of the cerebellum

abnormal cerebellum external granule cell layer morphology ( J:306384 )

• no clear separation of the inner and outer external granule cell layer

decreased cerebellar granule cell number ( J:306384 )

• at P6 in the inner granule layer

abnormal cerebellum anterior lobe morphology ( J:306384 )

• reduced length with failure of Purkinje cells to form a monolayer

• however, the posterior lobes are normal

cellular

increased neuronal precursor proliferation ( J:306384 )

• reduced fraction of granule cell precursors exiting the cell cycle in the anterior lobes of the cerebellum