Phenotypes Associated with This Genotype

Genotype
MGI:6718865

• Allelic Composition: Upf2^tm1Btp/Upf2^tm1Btp; En1^tm2(cre)Wrst/En1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuron apoptosis ( J:306384 )

• increased apoptotic cells in the cerebellum in both the ventricular zone and the prospective white matter

increased neuronal precursor proliferation ( J:306384 )

• in the ventricular zone progenitors at E13.5

abnormal cerebellum external granule cell layer morphology ( J:306384 )

• missing at E13.5 and P0

decreased inferior colliculus size ( J:306384 )

• grossly hypoplastic being nearly absent

decreased superior colliculus size ( J:306384 )

• grossly hypoplastic being nearly absent

cerebellum hypoplasia ( J:306384 )

• grossly being nearly absent

loss of GABAergic neurons ( J:306384 )

• at E13.5 in the cerebellum

cellular

increased neuron apoptosis ( J:306384 )

• increased apoptotic cells in the cerebellum in both the ventricular zone and the prospective white matter

increased neuronal precursor proliferation ( J:306384 )

• in the ventricular zone progenitors at E13.5