Phenotypes Associated with This Genotype

Genotype
MGI:6718853

• Allelic Composition: Hbs1l^{tm1c(KOMP)Wtsi}/Hbs1l^{tm1c(KOMP)Wtsi}; En1^tm2(cre)Wrst/En1⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuronal precursor proliferation ( J:306384 )

• more GABAergic precursors are retained between E12.5 and E16.5 due to increased proliferation

abnormal cerebellum morphology ( J:306384 )

• cerebellar defects are not rescued by restoration or complete deletion of n-TRtct5

abnormal cerebellar foliation ( J:306384 )

• delayed at P0 with failure of secondary fissures to form

• however, the trilaminar structure is normal at P21

decreased Purkinje cell number ( J:306384 )

• reduced ventricular zone-derived Lhx1/5+ Purkinje cells between E12.5 and E16.5

small cerebellum ( J:306384 )

• by E13.5

abnormal GABAergic neuron morphology ( J:306384 )

• more GABAergic precursors are retained between E12.5 and E16.5 due to increased proliferation

decreased neuronal precursor cell number ( J:306384 )

• reduced Pax2+ interneuron precursors between E12.5 and E16.5

• reduced granule cell precursors at E13.5 to E16.5

• reduced oligodendroglial progenitors at P5

• however, granule cell precursor proliferation is normal at E16.5 and P5

cellular

increased neuronal precursor proliferation ( J:306384 )

• more GABAergic precursors are retained between E12.5 and E16.5 due to increased proliferation