Analysis Tools
digestive/alimentary system
|
• at age 3 months
|
|
• few acinar lobules
|
|
• shorter primary cilia on ductal cells at age 3 months
|
endocrine/exocrine glands
|
• at age 3 months
|
|
• few acinar lobules
|
|
• shorter primary cilia on ductal cells at age 3 months
|
|
• 20% reduction of total islet volume
• 28% reduction of total large islet volume
• 22% reduction in number of large islets
|
|
• reduction in individual large islet volume
• 20% reduction of total islet volume
• 28% reduction of total large islet volume
|
|
• 65% reduction in pancreatic insulin levels
• normal glucose-stimulated insulin secretion by isolated islets in vitro
|
homeostasis/metabolism
| N |
• normal peripheral insulin sensitivity in insulin tolerance test (ITT) at age 24 weeks
|
|
• 65% reduction in pancreatic insulin levels
• normal glucose-stimulated insulin secretion by isolated islets in vitro
|
|
• at age 12 weeks
|
|
• higher blood glucose levels in the intraperitoneal glucose tolerance tests (IPGTT)
|
immune system
