Phenotypes Associated with This Genotype

Genotype
MGI:6715210

• Allelic Composition: Tg(CAG-Naa10)15Jprk/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

impaired osteoblast differentiation ( J:276208 )

• primary osteoblasts show inhibition of differentiation in culture upon induction with BMP-2

abnormal osteoblast physiology ( J:276208 )

• osteoblast surface per bone surface is lower in calvaria but the osteoblast number per bone perimeter is not altered indicating that bone development is delayed in calvarias because osteoblasts are less active

abnormal neurocranium morphology ( J:276208 )

• calvarial area, density, bone volume and thickness are reduced

• calvarial area, bone volume and density are decreased and mean bone separation is increased

abnormal fontanelle morphology ( J:276208 )

• calvarial fontanels are less closed and the bones are less dense

small neurocranium ( J:276208 )

• calvarial bones are smaller and less dense

thin neurocranium ( J:276208 )

• mean bone thickness is calvaria is decreased

abnormal femur morphology ( J:276208 )

• femurs are less developed on P3

decreased bone mineral density ( J:276208 )

• calvarial density is reduced

decreased bone volume ( J:276208 )

• bone volume to tissue volume is decreased in calvaria

craniofacial

abnormal neurocranium morphology ( J:276208 )

• calvarial area, density, bone volume and thickness are reduced

• calvarial area, bone volume and density are decreased and mean bone separation is increased

abnormal fontanelle morphology ( J:276208 )

• calvarial fontanels are less closed and the bones are less dense

small neurocranium ( J:276208 )

• calvarial bones are smaller and less dense

thin neurocranium ( J:276208 )

• mean bone thickness is calvaria is decreased

limbs/digits/tail

abnormal femur morphology ( J:276208 )

• femurs are less developed on P3

cellular

impaired osteoblast differentiation ( J:276208 )

• primary osteoblasts show inhibition of differentiation in culture upon induction with BMP-2

abnormal osteoblast physiology ( J:276208 )

• osteoblast surface per bone surface is lower in calvaria but the osteoblast number per bone perimeter is not altered indicating that bone development is delayed in calvarias because osteoblasts are less active