Phenotypes Associated with This Genotype

Genotype
MGI:6715097

• Allelic Composition: Fdxr^tm1Xch/Fdxr^tm1Xch
• Genetic Background: B6.Cg-Fdxr^tm1Xch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:244082 )

• homozygotes are alive at E7.0-E8.0 but resorbed at E8.5-E9.0; no live mice are born from heterozygous intercrosses

• embryonic lethality is likely due to iron overload

embryo

abnormal embryo development ( J:244082 )

• E8.0 embryos exhibit severe developmental defects

abnormal embryonic tissue morphology ( J:244082 )

• E7.5 embryos fail to develop normal layers of embryonic tissues

abnormal embryonic epiblast morphology ( J:244082 )

• failure to develop normal embryonic ectoderm

abnormal mesoderm morphology ( J:244082 )

• failure to develop normal mesoderm

abnormal extraembryonic tissue morphology ( J:244082 )

• E7.5 embryos fail to develop normal layers of extraembryonic tissues

abnormal extraembryonic ectoderm morphology ( J:244082 )

• failure to develop normal extraembryonic ectoderm

abnormal extraembryonic endoderm morphology ( J:244082 )

• failure to develop normal extraembryonic visceral endoderm

abnormal visceral endoderm morphology ( J:244082 )

• failure to develop normal visceral endoderm

homeostasis/metabolism

abnormal iron level ( J:244082 )

• Pearl's Prussian blue staining revealed extensive iron overload in E8.0 embryos