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Phenotypes Associated with This Genotype
Genotype
MGI:6705078
Allelic
Composition		 Cd74tm1Eae/Cd74tm1Eae
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Eae mutation (0 available); any Cd74 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased susceptibility to myocardial ischemic injury ( J:213776 )
• left ventricle contractile dysfunction is more pronounced and myocardial necrosis is 2-fold more pronounced in isolated perfused hearts during reperfusion after ischemia than in homozygous Miftm1Dvd or wild-type hearts
increased myocardial infarct size ( J:213776 )
• infract size is greater in isolated perfused hearts during reperfusion after ischemia than in homozygous Miftm1Dvd or wild-type hearts

homeostasis/metabolism
increased susceptibility to myocardial ischemic injury ( J:213776 )
• left ventricle contractile dysfunction is more pronounced and myocardial necrosis is 2-fold more pronounced in isolated perfused hearts during reperfusion after ischemia than in homozygous Miftm1Dvd or wild-type hearts
increased myocardial infarct size ( J:213776 )
• infract size is greater in isolated perfused hearts during reperfusion after ischemia than in homozygous Miftm1Dvd or wild-type hearts

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory