Phenotypes Associated with This Genotype

Genotype
MGI:6696404

• Allelic Composition: Mir34a^tm1.1Aven/Mir34a^tm1.1Aven; Mirc21^tm1.1Aven/Mirc21^tm1.1Aven; Mirc34^em1Jnch/Mirc34^em1Jnch
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:304721 )

• lethality occurs between P21 to P28 in some mice

postnatal lethality, incomplete penetrance ( J:304721 )

• lethality occurs between P7 and P14

behavior/neurological

jumpy ( J:304721 )

• in home cages and open arena

hunched posture ( J:304721 )

abnormal locomotor coordination ( J:304721 )

• uncoordinated hind tiptoe walking

decreased locomotor activity ( J:304721 )

• slight

• however, mice exhibit normal locomotor coordination running speed, temporal composition during the step cycle, and inter-limb coordination

decreased thermal nociceptive threshold ( J:304721 )

nervous system

nervous system phenotype ( J:304721 )

N • mice exhibit normal motor neuron numbers

abnormal motor neuron morphology ( J:304721 )

• mice exhibit altered number of sub-population of motor synergy encoder neurons compared with wild-type mice

growth/size/body

decreased body weight ( J:304721 )

postnatal growth retardation ( J:304721 )

vision/eye

microphthalmia ( J:304721 )

blepharoptosis ( J:304721 )