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Phenotypes Associated with This Genotype
Genotype
MGI:6695985
Allelic
Composition		 \Ightm1Mnz/\Ightm1Mnz
\Dis3tm1.1Uba/\Dis3tm1.1Uba
\Aicdatm1(cre)Uba/\Aicda+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1(cre)Uba mutation (0 available); any Aicda mutation (58 available)
Dis3tm1.1Uba mutation (0 available); any Dis3 mutation (41 available)
Ightm1Mnz mutation (5 available); any Igh mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal somatic hypermutation frequency ( J:302856 )
• mice immunized to induced somatic hypermutation show higher mutation frequencies in germinal center derived B cells
• the C to T mutation frequency is increased and inversely, the G to A mutation frequency is decreased in germinal cell B cells, indicating dysregulation of activation-induced cytidine deaminase activity at the V(D)J exon during somatic hypermutation

hematopoietic system
abnormal somatic hypermutation frequency ( J:302856 )
• mice immunized to induced somatic hypermutation show higher mutation frequencies in germinal center derived B cells
• the C to T mutation frequency is increased and inversely, the G to A mutation frequency is decreased in germinal cell B cells, indicating dysregulation of activation-induced cytidine deaminase activity at the V(D)J exon during somatic hypermutation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory