Phenotypes Associated with This Genotype

Genotype
MGI:6695984

• Allelic Composition: Dis3^tm1.1Uba/Dis3^tm1.1Uba; Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell morphology ( J:302856 )

• B cells exhibit altered chromosome architecture genome wide in tamoxifen-treated mice

abnormal class switch recombination ( J:302856 )

• B cells in vitro stimulated with tamoxifen exhibit a defect in class-switch recombination

• tamoxifen-treated B cells show a reduction to class-switch recombination to IgG1

• tamoxifen-treated mice show an increase in microhomology-mediated DNA junctions in B cells

hematopoietic system

abnormal B cell morphology ( J:302856 )

• B cells exhibit altered chromosome architecture genome wide in tamoxifen-treated mice

abnormal class switch recombination ( J:302856 )

• B cells in vitro stimulated with tamoxifen exhibit a defect in class-switch recombination

• tamoxifen-treated B cells show a reduction to class-switch recombination to IgG1

• tamoxifen-treated mice show an increase in microhomology-mediated DNA junctions in B cells