About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6695982
Allelic
Composition
Rab39bem1Jfch/Y
Genetic
Background
C57BL/6N-Rab39bem1Jfch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab39bem1Jfch mutation (0 available); any Rab39b mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• normal behavior and mobility in open field test
• normal behavior in marble burying test
• normal self-grooming behavior
• normal motor coordination and balance
• no increased latency to fall at days 2 and 3 in accelerated rotarod test (wild-type mice increase latency)
• no difference in interaction with novel mouse cage vs familiar mouse cage (wild-type mice spend more time with novel mouse)
• normal behavior in novel mouse cage vs empty cage test: more time spent with mouse

nervous system
• normal cortical thickness
• increased hemisphere length and cortical area at age P20
• at age P20 and in E18.5 embryos
• increased brain-to-body weight ratio
• normal cortical thickness
• increased Tbr1+ neurons in E16.5 embryos and Tbr1+ neurons and Ctip2+ neurons in E18.5 embryos
• increased Cux1+ neurons t age P20
• normal Cux1+ neurons in E18.5 embryos
• normal distribution of Tbr1+, Cux1+ and Ctip2+ neurons in embryos
• normal numbers of Tbr1+, Cux1+ and Ctip2+ neurons in E14.5 embryos
• increased Tbr1+ neurons in E16.5 embryos and Tbr1+ neurons and Ctip2+ neurons in E18.5 embryos
• increased Cux1+ neurons t age P20
• normal Cux1+ neurons in E18.5 embryos
• increased proliferation and decreased cell cycle exit of neuronal precursor cells (NPCs) in E14.5 embryos

growth/size/body
N
• normal body size, no gross dysmorphologies
• slightly decreased body weight at age P20
• increased brain-to-body weight ratio

mortality/aging
N
• viable

reproductive system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
syndromic X-linked intellectual disability DOID:0060309 OMIM:PS309510
J:287752


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/10/2022
MGI 6.19
The Jackson Laboratory