Phenotypes Associated with This Genotype

Genotype
MGI:6695906

• Allelic Composition: Myh3^tm1.2Sajm/Myh3^tm1.2Sajm
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased myoblast apoptosis ( J:287755 )

• at age P0

growth/size/body

decreased body weight ( J:287755 )

• low birth weight

mortality/aging

prenatal lethality, incomplete penetrance ( J:287755 )

• mice are born at about half the expected Mendelian ratio

muscle

increased myoblast apoptosis ( J:287755 )

• at age P0

abnormal muscle precursor cell morphology ( J:287755 )

• reduction in Pax7+ myogenic precursor cells and in levels of committed myoblast marker MyoD peptide in E16.5 embryos

• normal number of Pax7+ myogenic precursor cells at age P0

decreased skeletal muscle fiber diameter ( J:287755 )

• in soleus at age P0, tibialis anterior (TA) and gastrocnemius at ages P15 and P30 and EDL at P15

• in extensor digitorum longus (EDL) at ages P0 and P30

increased skeletal muscle fiber number ( J:287755 )

• in extensor digitorum longus (EDL) and soleus at age P0

decreased skeletal muscle weight ( J:287755 )

• of tibialis anterior (TA), gastrocnemius and quadriceps at ages P15 and P30

abnormal skeletal muscle fiber type ratio ( J:287755 )

• increased number of MYH7+ (MyHC-slow) fibers in hind limb at age P0 and tibialis anterior (TA) and gastrocnemius at age P15

• in extensor digitorum longus (EDL) at age P15 and tibialis anterior (TA) and gastrocnemius at age P30