Phenotypes Associated with This Genotype

Genotype
MGI:6693528

• Allelic Composition: A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0; Tg(CAG-cat,-Trim8)4Holi/0
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:303651 )

• no gross abnormalities in cardiac morphology or function

growth/size/body

growth/size/body region phenotype ( J:303651 )

• healthy, without gross abnormalities

mortality/aging

mortality/aging ( J:303651 )

• viable

increased susceptibility to induced morbidity/mortality ( J:303651 )

• increased cardiac hypertrophy and greater increase in heart weight to body weight (HW/BW) and tibia length (HW/TL) and lung weight to body weight (LW/BW) ratios and cardiomyocyte cross-sectional area 4 weeks after aortic banding

• increased extent of cardiac interstitial and perivascular fibrosis 4 weeks after aortic banding

• more cardiac ventricular dilation (increased left ventricle end-systolic and end-diastolic dimension) and greater decrease of fractional shortening 4 weeks after aortic banding

reproductive system

reproductive system phenotype ( J:303651 )

• fertile