Phenotypes Associated with This Genotype

Genotype
MGI:6690625

• Allelic Composition: Ptprt^m1Rgsc/Ptprt^m1Rgsc
• Genetic Background: C57BL/6J-Ptprt^m1Rgsc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

impaired neuron differentiation ( J:298303 )

• newborn granule cells exhibit delayed development with reduced doublecortin expression and neurite length compared wild-type cells

abnormal excitatory synapse morphology ( J:298303 )

• decreased in hippocampal neurons

abnormal inhibitory synapse morphology ( J:298303 )

• decreased in hippocampal neurons

enhanced long-term potentiation ( J:298303 )

abnormal miniature inhibitory postsynaptic currents ( J:298303 )

• decreased in the dentate gyrus

behavior/neurological

behavioral despair ( J:298303 )

• in a tail suspension test, forced swim test, and sucrose preference test

• however, treatment with imipramine reduced depression-like behaviors

homeostasis/metabolism

decreased gamma-aminobutyric acid level ( J:298303 )

• reduced GABA levels in the hippocampus

decreased glutamine level ( J:298303 )

• in the hippocampus

cellular

impaired neuron differentiation ( J:298303 )

• newborn granule cells exhibit delayed development with reduced doublecortin expression and neurite length compared wild-type cells