Phenotypes Associated with This Genotype

Genotype
MGI:6515626

• Allelic Composition: Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig; Tg(Nkx2-1-cre)2Sand/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

impaired neuron differentiation ( J:301083 )

• marker analysis suggests that the development of GHRH-neurons, rather than just the expression of Ghrh, is impaired in mutant mice

• however, the number of AgRP-neurons is unchanged and neither Sf1+ or Trh+ cell numbers are altered

decreased neuron number ( J:301083 )

• growth hormone-releasing hormone (GHRH)-producing neurons expressing Ghrh and Th are reduced at E14.5-E15.5, indicating that development of GHRH-neurons is impaired

• mice show a reduction of GHRH-neurons at P65

homeostasis/metabolism

decreased circulating glucose level ( J:301083 )

cellular

impaired neuron differentiation ( J:301083 )

• marker analysis suggests that the development of GHRH-neurons, rather than just the expression of Ghrh, is impaired in mutant mice

• however, the number of AgRP-neurons is unchanged and neither Sf1+ or Trh+ cell numbers are altered